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Many people using semaglutide have experienced significant reductions in body weight, making it one of the top choices for managing obesity today

In addition, knockdown of HMGB1 reduced erastin-induced ROS generation and suppressed TfR1 expression through the RAS-JNK/p38 pathway, thereby regulating ferroptosis (Ye et al., 2019)

As the ESSENCE trial (still recruiting) clinicaltrials.gov/ct2/show/NCT04 examines semaglutide 2.4mg weekly for the treatment of #NASH do we fully understand the indirect and direct actions of GLP-1R signaling that reduce steatosis and #inflammation Does it matter

However, its use may be associated with gastrointestinal side effects such as nausea and vomiting