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In human lens epithelial cells, 50250 M melatonin decreases H 2 O 2 -induced intracellular ROS generation by activating the PI3K/Akt signaling pathway (114) and inhibits UVB-promoted ferroptosis by regulating two Sirt6 (Nrf2 or nuclear receptor coactivator 4) pathways (115,116)

Unlike the gold-standard Levodopa, which primarily alleviates symptoms but paradoxically generates iatrogenic ROS through auto-oxidation (Scigliano et al., 1997), bilirubin acts as an endogenous disease-modifying agent that specifically neutralizes such oxidative burdens ( In summary, bilirubin provides a new biological perspective for PD prevention and treatment through multiple mechanisms, including antioxidant, anti-inflammatory, anti-ferroptosis effects, and potential neural development regulation

GLP-1s control appetite while Lipo C optimizes fat metabolism