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Hum.Exp.Toxicol

GSH as a Cysteine Reservoir One of the most important functions of GSH is the storage of cysteine, given its high extracellular instability that rapidly auto-oxidizes to cystine (the oxidized dimer form of cysteine) [8]

This insight has guided Fc-engineering of IgG variants with improved pH-dependent FcRn binding, resulting in antibodies with extended plasma half-life in human FcRn transgenic mice, non-human primates (NHPs) as well as humans 10,23,24,25