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Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidismrole of triiodothyronine in pituitary feedback in humans

Besides the well-known targets such as the inhibition of the mTOR signaling pathway, several additional metformin and phenformin targets (e.g., mGPDH, ATF3, STAT3, GSK3, cyclins) have been identified in other cancers (Thakur et al., 2019)