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When to Seek Urgent or Emergency Care Stop the infusion and seek urgent medical evaluation for: Trouble breathing, wheezing, throat tightness, facial or tongue swelling, widespread hives, or fainting Persistent chest pain or pressure, severe shortness of breath, irregular heartbeat, or loss of consciousness Severe chills, shaking, high fever, confusion, very low blood pressure, or concern for contaminated product or bloodstream infection Sudden weakness, speech difficulty, severe headache, seizure, or another acute neurologic symptom Severe IV-site pain, rapidly increasing swelling, pale or cool skin, blistering, or loss of sensation A symptom occurring during an infusion should not automatically be labeled a detox reaction. That phrase can delay recognition of allergy, endotoxin exposure, infection, excessive infusion rate, cardiac symptoms, anxiety, or another medical problem