DMRT2 Rabbit Polyclonal Antibody, 100ul Molecular Weight Markers and domains IV and VI

and domains IV and VI have a globular conformation

a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53

This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception

Alternative splicing results in two transcript variants encoding different isoforms

DMRT2 Rabbit Polyclonal Antibody, 100ul Molecular Weight Markers and domains IV and VIThe protein encoded by this gene belongs to the DMRT gene family sharing a DM DNA binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3 genes involved in sex determination in these organisms. Also this gene is located in a region of the human genome (chromosome 9p24. 3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex determining gene(s) on chr 9.