Seek urgent medical attention (call 999 or go to A&E) if you experience: Chest pain, severe breathlessness, or fainting episodes Severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis Contact your GP or diabetes care team promptly if you experience: Severe or persistent fatigue lasting beyond the initial adaptation period Signs of dehydration including dark urine, dizziness on standing, reduced urine output, or persistent dry mouth Symptoms of hypoglycaemia particularly if recurrent, or if you're unable to recognise warning signs Significant unintentional weight loss exceeding clinical targets (typically more than 0.5-1kg per week) Inability to maintain adequate nutrition or hydration due to gastrointestinal side effects New or worsening depression, anxiety, or mood changes affecting daily functioning Right upper abdominal pain, fever or yellowing of the skin/eyes which could indicate gallbladder disease Pregnancy or planning pregnancy tirzepatide is not recommended during pregnancy and should be discontinued Symptoms of sleep apnoea loud snoring, witnessed breathing pauses during sleep, excessive daytime sleepiness Your GP may wish to perform investigations to exclude other causes of fatigue, which might include: Blood tests full blood count (to check for anaemia), thyroid function tests, vitamin B12 and folate levels, iron studies, renal and liver function, and HbA1c Review of concurrent medications to identify potential drug interactions or cumulative side effects Assessment of diabetes control including review of blood glucose monitoring data In some cases, dose adjustment, temporary treatment interruption, or switching to an alternative medication may be appropriate
Alexander Shapsis , a Board-Certified Specialist in Gastroenterology and Obesity Medicine, is here to guide you every step of the way
Foods in their natural state, such as fruits, vegetables, meat, fish, seafood, legumes, nuts, seeds, and whole grains, will help you feel fuller for longer and manage blood sugar levels to avoid energy crashes that often lead to overeating
This analysis suggests that the greater effects of tirzepatide may allow more individuals to achieve glycaemic and non-glycaemic therapeutic targets
