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The primary objective was to evaluate the models ability to produce accurate probability estimates using Minimal Significant Difference (MSD) as a test case by analyzing patient-specific variablesincluding demographics, baseline patient-reported outcome (PRO) scores, Patient Global Impression of Change (PGIC) as the anchor, clinical measurements, and treatment history

Ventricular CSF was collected intraoperatively during VPS surgery, providing direct access to central nervous system metabolic profiles

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