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Funding This article was supported by the Natural Science Foundation of China (32200154 to J.Y.), the Natural Science Foundation of China (82203031 to Y.L.)

In addition, low glutathione levels are linked to impaired mitochondrial function and reduced fatty acid oxidation , both of which contribute to insulin resistance (4)

Another prospective study demonstrated that the same reduced functional variants of OCT1 (M420del, R61C, G465R, and G401S) were linked to trough concentrations of metformin and progress in HbA1c post 6 months of metformin treatment in a group of 151 diabetic patients in South Danish cohort (Christensen et al., 2011)