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N Engl J Med 2019;381:63746

Biol Psychiatry 2014;75:855863.ArticlePubMed 55

[40] These results, published in the New England Journal of Medicine in 2009, showed that EPP patient's "tolerance to artificial light and melanin density increased significantly by day 120 after the start of afamelanotide, to 11 times and 1.3 times the baseline values"