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[1] [2] Administered as a weekly subcutaneous injection, this medication works by enhancing insulin secretion in response to meals, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways

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Hence, the findings that tamoxifen resistance is associated with increased enolase I expression is consistent with the premise that tamoxifen selectively targets P-gp-expressing tumor cells which have higher ATP needs to fuel P-gp