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It disrupts the structural integrity of cell membranes, but due to the incidence of hepatotoxicity, the drug was eliminated from clinical trials [151]

for continued protection

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As class B1 peptide agonists engage their receptors via a two-domain interaction, their efficacy for G protein-mediated signalling is influenced by multiple factors, including the nature of interactions with the ECD and TMD, contributing to both peptide affinity and how ligandreceptor interactions influence G protein binding, nucleotide exchange and G protein dissociation from the receptor