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The inability to definitively establish causality is a constraint shared by all pharmacovigilance studies and observational cohort studies [Reference Ruiz, Cocores, Tosti, Goadsby and Monteith50, Reference Wichelmann, Abdulmujeeb and Ehrenpreis51]

Using laxatives can be helpful in the short term but it is far more beneficial to address the underlying issues of constipation and correct fluid and fibre intake or address food intolerances, particularly dairy containing foods which can often be the culprit

TUDCA inhibits the expression of FXR and fatty acid transport protein 5 (FATP5), thereby reducing fatty acid absorption and hepatic lipid accumulation, enhancing intestinal barrier function, and promoting the growth of Allobaculum and Bifidobacterium (Wang et al., 2024b)

Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for prevention and treatment of BBB dysfunction