NPL4 Polyclonal Antibody, 100ul 3D Culture Aberrant expression of this gene

Aberrant expression of this gene in adult tissues is associated with tumorigenesis

Mutations in this gene have been associated with autism and Asperger syndrome

Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases| which localize to the mitochondrial matrix| and two NADP(+)-dependent isocitrate dehydrogenases| one of which is mitochondrial and the other predominantly cytosolic

tissue specificity:Highly expressed in brain

NPL4 Polyclonal Antibody, 100ul 3D Culture Aberrant expression of this geneBinds ubiquitinated proteins via its RanBP2 type zinc finger.,The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4 UFD1L VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway: Protein degradation;