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The histopathological changes in the kidney of the MSG group were defined by membranoproliferative glomerulonephritis and hyaline casts in the Bowmans space and renal tubular lumens (Figures 1C,D)

Another study found a strong association between plasma TNF- levels and KYN as well as KYN/TRP ratios, and patients with higher levels showed greater MDD severity and poor treatment response [104]