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Since this study did not employ a crossover design and the information on dosing time relied on patients self-report and compliance, a randomized, double-blind, placebo-controlled, crossover trial by the same research group in 2016 aimed to provide more solid evidence (98)

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Notable observations post-administration include a marked increase in daytime activity, the erasure of circadian rhythms ( Pharmacological intervention Experimental groups were established, each comprising 6 model mice and 6 control mice