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NO promotes mitochondrial biogenesis primarily by activating key transcriptional regulators, including peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), nuclear respiratory factor (Nrf-1), nuclear factor erythroid 2 -related factor 2 (Nrf-2), and mitochondrial transcription factor A (TFAM)

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A limitation of the study is the necessity for in vitro and further in vivo studies to investigate additional protective mechanistic pathways of MCP against MTX-induced hepatic and pulmonary toxicity