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There is normally a feedback mechanism that regulates glycocalyx synthesis and degradation, but the rate of degradation is much higher than the rate of synthesis in the pathologic state

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High doses of ascorbate (1 g/kg) blocked dopamine mediated circling behavior, something that may also be achieved through dopamine receptor blockers [1];ascorbate inhibit binding of specific D 1 and D 2 receptors [13]

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