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Iron regulatory proteins (IRPs), bind to iron-responsive elements (IREs) in the 5 untranslated region (UTR) of mRNAs encoding ferritin and FPN1 to inhibit their translation, while binding to IREs in the 3 UTR of TfR1 and DMT1 mRNAs to stabilize these transcripts, thereby adjusting iron storage, export, and uptake (41, 58)

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Inappropriate ROS formation has many deleterious cellular consequences, including the formation of DNA damage 51

Visceral fat targeting: Growth hormone particularly affects visceral fat, the metabolically dangerous fat around internal organs