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Copper peptides should be avoided by anyone with a known copper allergy, those with active inflammatory skin conditions like a rosacea flare or severe eczema, anyone whose skin barrier is severely compromised, and (until more research is available) those who are pregnant or breastfeeding

A pharmacology that keeps amylin receptors tonically engaged, day and night, may reproduce amylins central appetite effects (which appear to tolerate sustained stimulation reasonably well) while behaving quite differently at the level of the stomach, where continuous braking could invite adaptive counter-regulation