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PMC 3801446

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However, contrasting findings were observed in another study (64), which serum disulfide levels were observed to decrease in AD children in comparison to healthy children, leading to a reduction in the disulfide/natural thiol and disulfide/total thiol ratios

Structural evidence for the movement of a phenol group in a tyrosine residue, oriented roughly perpendicular to the FAD with the binding of NADPH has also been reported for GR (Karplus and Schulz, 1987) and similar positioning in TrxR has also been implied (Silvestri et al., 2018)