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The HPA axis, functioning as the neuroendocrine system's master regulator, exhibits intrinsic circadian oscillations in both its basal tone and stress-responsive activity (121).Key HPA effector molecules, particularly glucocorticoids and angiotensin II, modulate BBB permeability in a phase-dependent manner by regulating tight junction proteins (claudin-5, ZO-1) and vascular permeability factors such as VEGF (122125)

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Accordingly, taking probiotics may serve as a way to optimize these facets of physiological function to counteract aspects of aging

TGR inhibitors target a reduced form of TGR Next, we investigated if the TGR redox state affects the binding and activity of the inhibitors