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However, there is no official contraindication based solely on heart rate considerations, and these medications can be used safely in most patients with cardiovascular disease under appropriate medical supervision

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Given the potential strain on joints from GLP-1 medications, the program emphasizes low-impact strength exercises to support joint health while preserving muscle and burning fat

These findings indicate that GLP-1RAs have anti-adhesive and anti-thrombotic properties in the endothelium that may delay the development of atherosclerosis [110]