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PFI-2 Hydrochloride FKBP Degrader-3 It reduces antigen-induced histamine release

PFI-2 Hydrochloride FKBP Degrader-3 It reduces antigen-induced histamine release

Name: PFI-2 Hydrochloride FKBP Degrader-3 It reduces antigen-induced histamine release
Brand: matisco.be
SKU: 24264607827
Price: 122.00 USD
Availability: InStock
Rating: 4.5643 (19 reviews)

SKU: 24264607827

4.6

PLN122.00 PLN165.00

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PFI-2 Hydrochloride FKBP Degrader-3 It reduces antigen-induced histamine releasePFI 2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000 fold selectivity over other methyltransferases and other non epigenetic targets. PFI 2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI 2 interacts with SETD7 in pull down studies. Its enantiomer (S) PFI 2 is 500 fold less active making it an excellent negative control. Treatment of low density MEFs with (R) PFI 2 resulted in higher nuclear YAP levels indicating an

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Description

It reduces antigen-induced histamine release from rat conjunctival tissue by 46% in vitro when used at a concentration of 10 µg/ml

5 and 4 mg/L for streptococci

Solubility: DMSO: 65 mg/mL(199

1379686-30-2

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