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Extracted variables included study characteristics (e.g., sample size, followup duration, and region), patient demographics, and inclusion criteria focusing on patients diagnosed with overweight, obesity, and/or T2DM with at least 12 weeks of followup

Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)

The concentrate was diluted with 20 mL of deionized water and cooled to 0 C

Exosomes as new generation vehicles for drug delivery: biomedical applications and future perspectives