Cables1 Polyclonal Antibody, 100ul Micro Centrifuge Tubes This protein binds to DNA

This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE)

The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9| Enhancer-of-zeste| Trithorax) domain and may function as a histone methyltransferase

MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases

A deletion downstream of SOST

Cables1 Polyclonal Antibody, 100ul Micro Centrifuge Tubes This protein binds to DNACABLES1 encodes a protein (Cdk5 and Abl enzyme substrate 1) involved in regulation of the cell cycle through interactions with several cyclin dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127). Multiple transcript variants encoding