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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

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With respect to gene structure, the CsGST genes in the same class were similar in the number and position of introns and exons and had similar motifs (Figure 1)

The injection experience is largely comparable, with pre-filled pens designed for patient self-administration