DNA Ligase I Polyclonal Antibody, 20ul Reservoirs It functions as a transcriptional
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DNA Ligase I Polyclonal Antibody, 20ul Reservoirs It functions as a transcriptionalLIG1 encodes a member of the ATP dependent DNA ligase protein family. DNA ligase 1 functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA damaging agents. Disruption of LIG1 may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
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