IRS-1 Polyclonal Antibody, 100ul[BT-AP04647] Purification it consists of a 35-kD

it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520)

Two alternative transcripts encoding the same protein have been described

cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits

This encoded protein acts preferentially as a receptor for NTN compared to its other family member

IRS-1 Polyclonal Antibody, 100ul[BT-AP04647] Purification it consists of a 35-kDIRS1 encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.