Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler Alternatively spliced transcript variants have

Alternatively spliced transcript variants have been found for this locus

There is a microRNA gene located within the 5' exon of this gene

Gene Ontology (GO) annotations related to this gene include serine-type endopeptidase inhibitor activity

The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes

Rb (Acetyl-K873/K874) Polyclonal Antibody, 50ul Pipette Filler Alternatively spliced transcript variants haveThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.