DSC3 Polyclonal Antibody, 100ul Plasmid Preparation Defects in MEGF8 are a

Defects in MEGF8 are a cause of Carpenter syndrome 2

including murine leukemia virus

Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain

An important paralog of this gene is JMJD7-PLA2G4B

DSC3 Polyclonal Antibody, 100ul Plasmid Preparation Defects in MEGF8 are aThe protein encoded by this gene is a calcium dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on