Rat Interleukin 10, IL-10 ELISA Kit, 96T Cell Senescence PubMed: 16846591

PubMed: 16846591

Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6)

Multiple alternatively spliced transcript variants have been identified in this gene

Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy

Rat Interleukin 10, IL-10 ELISA Kit, 96T Cell Senescence PubMed: 16846591Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2 mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti inflammatory mediators. Targets