Rat Bone Morphogenetic Protein 2, BMP-2 ELISA Kit , 96T Cellular Cultivation & Health Management PubMed: 14672706

PubMed: 14672706

Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense

|PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1

Involved in initiation and maintenance of cell cycle exit during cell differentiation

Rat Bone Morphogenetic Protein 2, BMP-2 ELISA Kit , 96T Cellular Cultivation & Health Management PubMed: 14672706Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3 EIF2A ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.