TPH1 Polyclonal Antibody, 50ul[BT-AP09150] Enzyme Activity Assays Mutations in this gene may

Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome

Mutations in CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndorome

both domains are DNA-binding motifs

A related pseudogene has been identified on chromosome 17

TPH1 Polyclonal Antibody, 50ul[BT-AP09150] Enzyme Activity Assays Mutations in this gene mayTPH1 (tryptophan hydroxylase 1) encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in TPH1 have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger related traits, bipolar disorder, suicidal behavior, addictions, and