M3K14 Polyclonal Antibody, 100ul Plates & Dishes Two splice variants encoding different

Two splice variants encoding different isoforms have been found for this gene

A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA

Mutations in this gene cause porencephaly

gliomas and metastatic bone disease

M3K14 Polyclonal Antibody, 100ul Plates & Dishes Two splice variants encoding differentThis gene encodes mitogen activated protein kinase kinase kinase 14, which is a serine threonine protein kinase. This kinase binds to TRAF2 and stimulates NF kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF kappaB inducing signalling cascade common to receptors of the tumour necrosis nerve growth factor (TNF NGF) family and to the interleukin 1 type I receptor.