LRP3 Polyclonal Antibody, 20ul Dialysis Although the five genes share

Although the five genes share a remarkably high degree of sequence identity

which sequester the cytosol and organelles for degradation by lysosomes

this enzyme may be involved in such varied processes as gluconeogenesis

The main portion of the receptor is a heterodimer composed of 2 polypeptide chains

LRP3 Polyclonal Antibody, 20ul Dialysis Although the five genes shareNLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 and 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle Wells autoinflammatory syndromes. Mouse NLRP3 contains an N terminal Pyrin domain (aa 1 91) followed by a Nacht region (aa 216 532), and seven LRRs (aa 739 988). Within