Rat Tissue-type Plasminogen Activator, TPA ELISA Kit, 96T Lysosome Several transcript variants encoding different

Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene

The protein encoded by HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors

Binds to cyclins A and E

but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP

Rat Tissue-type Plasminogen Activator, TPA ELISA Kit, 96T Lysosome Several transcript variants encoding differentConverts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg Val bond in plasminogen. By controlling plasmin mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (PubMed: 1515147).