4E-BP1 Monoclonal Antibody, 50ul[BT-MCA0091] Bio-Reaction Tube When the gene product is

When the gene product is added to the spliceosome complex

and down-regulation

PML is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL)

It localizes primarily within subnuclear foci associated with the nuclear matrix

4E-BP1 Monoclonal Antibody, 50ul[BT-MCA0091] Bio-Reaction Tube When the gene product isThis gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV