UBP18 Rabbit Polyclonal Antibody, 50ul Yeast Expression Sequence data revealed that c-mpl

Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily

the first region lacks the essential Glu active site residue at position 241

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains| Fbls containing leucine-rich repeats| and Fbxs containing either different protein-protein interaction modules or no recognizable motifs

also known as Amish nemaline myopathy

UBP18 Rabbit Polyclonal Antibody, 50ul Yeast Expression Sequence data revealed that c-mplThe protein encoded by this gene belongs to the ubiquitin specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin like protein) fusions and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues indicating that this protein is a major