Phospho-Amyloid-Beta (T743) Polyclonal Antibody, 100ul Deep Well Plates Mutations in this gene have

Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum

cholesterol

This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3)

May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles

Phospho-Amyloid-Beta (T743) Polyclonal Antibody, 100ul Deep Well Plates Mutations in this gene haveAPP encodes a cell surface receptor and transmembrane precursor protein (amyloid beta precursor protein) that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1 TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are