RFX5 Rabbit Polyclonal Antibody, 20ul Mini dry bath Alternatively spliced transcript variants encoding

Alternatively spliced transcript variants encoding different isoforms have been noted for TMPO

which is essential for the biosynthesis of isoprenoid-derived lipids

The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex

It is a mediator of mitochondrial damage induced by caspase-8 (CASP8)| CASP8 cleaves this encoded protein

RFX5 Rabbit Polyclonal Antibody, 20ul Mini dry bath Alternatively spliced transcript variants encodingA lack of MHC II expression results in a severe immunodeficiency syndrome called MHC II deficiency or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B cell lines established from patients with BLS. The molecular defects in complementation groups B C and D all lead to a deficiency in RFX a nuclear protein complex that binds to the X box of MHC II promoters. The lack of RFX binding activity in