Human Beta, Beta-Carotene 9', 10'-Oxygenase, BCO2 ELISA Kit, 96T Vortex Mixer and CSF2 form a cytokine

and CSF2 form a cytokine gene cluster on chromosome 5q

but not in muscle (PubMed: 17908561)

This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C| 1

These enzymes hydrolyze a variety of dipeptides| including leukotriene D4| the beta-lactam ring of some antibiotics| and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al

Human Beta, Beta-Carotene 9', 10'-Oxygenase, BCO2 ELISA Kit, 96T Vortex Mixer and CSF2 form a cytokineAsymmetrically cleaves beta carotene at the 9',10' double bond resulting in the formation of beta apo 10' carotenal and beta ionone. Besides beta carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.