Parkin Polyclonal Antibody, 20ul Cell Culture Plates Alternate splicing of this gene

Alternate splicing of this gene results in multiple transcript variants encoding different isoforms

Defects in PEX7 cause peroxisome biogenesis disorders (PBDs)

inducing leukocyte migration and activation

It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region

Parkin Polyclonal Antibody, 20ul Cell Culture Plates Alternate splicing of this geneThe precise function of PARK2 is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in PARK2 are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of PARK2 produces multiple transcript variants encoding distinct isoforms. Additional splice variants of PARK2 have