PBIP1 Rabbit Polyclonal Antibody, 20ul Cell Dissociation TOP2A encoding this enzyme functions

TOP2A encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance

This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C

that is involved in transcription initiation and DNA repair

The functional enzyme is thought to be a homodimer which uses FAD as a cofactor

PBIP1 Rabbit Polyclonal Antibody, 20ul Cell Dissociation TOP2A encoding this enzyme functionsThe protein encoded by this gene interacts with the PBX1 homeodomain protein inhibiting its transcriptional activation potential by preventing its binding to DNA. The encoded protein which is primarily cytosolic but can shuttle to the nucleus also can interact with estrogen receptors alpha and beta and promote the proliferation of breast cancer brain tumors and lung cancer. Several transcript variants encoding different isoforms have been found for