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EKLF (Acetyl Lys274) Rabbit Polyclonal Antibody, 20ul Antibody Humanization A mutation in the mouse

SKU: 6147632847

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EKLF (Acetyl Lys274) Rabbit Polyclonal Antibody, 20ul Antibody Humanization A mutation in the mouseThis gene encodes a hematopoietic specific transcription factor that induces high level expression of adult beta globin and other erythroid genes. The zinc finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss of function mutations in this gene result in the dominant In(Lu) blood phenotype.

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Description

A mutation in the mouse ortholog of this gene results in homeotic| posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants

As a member of the ERM protein family

an essential step in the biosynthesis of PtdInsPs (Barylko et al

Related pseudogenes have been defined on the X chromosome

EKLF (Acetyl Lys274) Rabbit Polyclonal Antibody, 20ul Antibody Humanization A mutation in the mouseThis gene encodes a hematopoietic specific transcription factor that induces high level expression of adult beta globin and other erythroid genes. The zinc finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss of function mutations in this gene result in the dominant In(Lu) blood phenotype.

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