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These findings indicate that DNA damage can directly cause oligodendrocyte dysfunction and prevent the formation of myelinating oligodendrocytes

Therefore, we will focus on the characteristics of three important transport proteins: URAT1 and GLUT9, which are associated with uric acid reabsorption, and ABCG2, which is involved in uric acid excretion [53]

But it also acts on GIP, or glucose-dependent insulinotropic polypeptide, to slow gastric emptying and reduce levels of a hormone called glucagon which stimulates blood sugar release

Table 1, includes studies showing that Empagliflozin improved oxidative stress markers and NYHA functional class in T2DM patients with HFrEF (Eshraghi et al., 2025), and Dapagliflozin reduced the number of AHREs and improved oxidative stress/mitochondrial function in the clinical AF subgroup of patients with CIEDs (Nantsupawat et al., 2024)