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Potential Role of GLP-1 The GLP-1 receptor is widely distributed throughout the body with multiple biological effects, such as reducing neuroinflammation, promoting nerve growth, improving heart function, suppressing appetite, delaying gastric emptying, regulating blood lipid metabolism, and reducing fat deposition

Rhythm Pharmaceuticals, the developer of setmelanotide, has successfully pursued regulatory approval for the drug (marketed as IMCIVREE) in conditions caused by upstream defects in the MC4R pathway, such as POMC and LEPR deficiencies, where the receptor itself is intact, and the agonist mechanism is highly effective [57]

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But over time researchers also noticed that, Hey, it looks like people are eating less on this drug. And they found out that it also influences satiety levels, people feel fuller faster, and you eat less and therefore lose weight