IL-12B p40 Polyclonal Antibody, 50ul Subcellular Fractions Mutations in CASP10 are associated

Mutations in CASP10 are associated with type IIA autoimmune lymphoproliferative syndrome

No trypsin: preserves cell surface proteins and marker integrity

This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined

Contains 1 myosin head-like domain

IL-12B p40 Polyclonal Antibody, 50ul Subcellular Fractions Mutations in CASP10 are associatedThis gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to