Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette Mutations in TUBA1A cause lissencephaly

Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly

The protein encoded by this gene is a member of the shugoshin family of proteins

May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity

Alternative splicing results in multiple transcript variants encoding distinct isoforms

Rat Glypican-3, GPC-3 ELISA Kit, 96T Electronic Pipette Mutations in TUBA1A cause lissencephalyCell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical