TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody, 50ul Immunology The up-regulation of this gene

The up-regulation of this gene is found to be associated with a number of infectious diseases

The checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor

Mutations in this gene have been associated with hereditary hemochromatosis type III

Alternatively spliced transcript variants encoding the same protein have been found for this gene

TPOR(Phospho-Tyr626) Rabbit Polyclonal Antibody, 50ul Immunology The up-regulation of this geneIn 1990 an oncogene v mpl was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue named c mpl was cloned. Sequence data revealed that c mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti sense oligodeoxynucleotides of c mpl inhibited megakaryocyte colony